While in general I take a dim view of "new school" hip-kids-in-skinny-jeans type games like Dogs in the Vineyard, I do think its core idea of giving the player characters real power (perhaps ultimate power) over the people in the game world is quite a compelling one. Essentially, it's a surefire way of getting the PCs to engage with the game world, each other, and their own characters' beliefs, in a very direct way.
If I was going to run it, though, I think I would set it up more like the Book of Judges, because:
a) There is more scope for smiting, and
b) You know, Samson killing 1,000 Philistines with the jaw bone of an ass, and stuff.
The Bible is a very underdeveloped resource for RPGs. I suppose you can put this down to two things - firstly, fewer kids these days being forced (like I was) to go to Sunday School every week, thus less familiarity with the source material, and secondly, a lingering fear of RPGs being seen as some sort of blasphemous satan-worship-enabler. But the Old Testament and the Talmud, not to mention the Apocrypha, are great sources of adventure (and vignette) material. I'll explore a few of these over the coming days.